Loosely based on the film of the same name, this show features Beetlejuice, a wild ghost from the "Neitherworld," and his mortal best friend, a young girl named Lydia. Lydia loves everything spooky and morbid, causing her parents, friends and classmates to wonder about her. So, to escape from blonde snobs and homework, she calls on her best friend: the Ghost with the Most, Beetlejuice. The rude prankster takes his good-hearted mortal companion on many adventures in his home the Netherworld.